HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1196998Generated: October 25, 2026
Trifluoroacetic acid → Methyl 11-[2-(4-methylpiperazino)ethylidene]-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate
https://huagongshe.com/reaction/1196998
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 10106958 | HCID 10106958 | — |
| Solvent | 1,1,1,2-Tetrachloroethane | HCID 12418 | — |
| Product | Methyl 11-[2-(4-methylpiperazino)ethylidene]-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate | HCID 53817464 | — |
Reaction Steps
In this example, 1.5 ml of 4-methylpiperazine and 0.37 g of p-formaldehyde are dissolved in 100 ml of tetrachloroethane. To the solution is dropwise added 5 ml of trifluoroacetic acid. After stirring the mixture at 60° C. for 2 hours, a solution obtained by dissolving 1.8 g of methyl 11-methylene-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate in 30 ml of tetrachloroethane is dropwise added thereto and the mixture is stirred at 90° C. for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05116863 |
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| Source dataset | uspto-grants-1992_05 |
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| ORD ID | ord-dd85462a8011414d902cbb2eb0f2ae75 |
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| Source note | uspto-grants-1992_05 |
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