Ethyl Nitrite → HCID 22844254, compound

HRID 1197006Notes

Reaction equation

HRID 1197006 reaction equation
[ClH:1].[NH2:2][C@H:3]([C:21]([OH:23])=[O:22])[CH2:4][CH2:5][C:6]([NH:8][C@@H:9]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[C:10]([SH:13])([CH3:12])[CH3:11])=[O:7].[N:24](OCC)=[O:25].Cl.CO>CO.C(O)C>[ClH:1].[NH2:2][C@H:3]([C:21]([OH:23])=[O:22])[CH2:4][CH2:5][C:6]([NH:8][C@H:9]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[C:10]([S:13][N:24]=[O:25])([CH3:11])[CH3:12])=[O:7]

Participants

6

Reactant 3

HCID 8026Ethyl NitriteHCID 21893726Hydrochloride methanolHCID 22844249HCID 22844249, compound

Product 1

HCID 22844254HCID 22844254, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

To the solution of (N-γ-L-glutamyl-D-penicillamyl)glycine hydrochloride (0.5 g) in methanol (5 ml), was added at 0° C. the solution of ethyl nitrite in ethanol (10%) (1.1 ml). At the same temperature a drop of 4N-hydrochloric acid-methanol solution was added, and the mixture was stirred for 30 minutes. The solvent was evaporated off under reduced pressure, and the resultant crystals were washed with diethyl ether, to give (N-γ-L-glutamyl-S-nitroso-L-penicillamyl)glycine hydrochloride (0.5 g).

Workup

  1. customThe solvent was evaporated off under reduced pressure
  2. washthe resultant crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-ef22e8d6d45345b3ada4fdb69faa19d7
Source dataset
uspto-grants-1992_05
Patent number
US05116861

Reaction notes

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