Water → HCID 14423207, compound

Participants

Reaction Steps

Reflux a solution of (2-bromophenyl) [2-(1-pyrrolidinyl)-1-cyclopenten-1-yl]-methanone (14.1 g) (from Preparative Example 1) in benzene (100 ml) containing aniline (4.5 ml) and p-toluenesulfonic acid monohydrate (8.8 g) for 19 hrs. Remove water continuously with a Dean-Stark trap. Wash the cooled solution with water, 1M NaHCO3 solution, and with water. Dry the benzene solution, filter it, and evaporate the solvent. Crystallize to obtain (2-bromophenyl) [2-(phenylamino)-1-cyclopenten-1-yl]-methanone, m.p. 106.5°-108.5° from CH3CN.

Provenance & Evidence