Methanol → HCID 178512188, compound

HRID 1197069Notes

Reaction equation

HRID 1197069 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10].Cl.CC(O)=O.CO>CCOCC>[NH2:1][C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10]

Participants

5

Reactant 3

HCID 887MethanolHCID 22641269Acetate-hydrochloric acidHCID 178454200HCID 178454200, compound

Product 1

HCID 178512188HCID 178512188, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

BOC-Arg(NO2)-CHA, 45.4 g (0.1 mole), was dissolved in 300 ml (0.6 mole) of 2N HCl/AcOH and a small amount of MeOH. The solution was reacted at room temperature for 2 hours. After completion of the reaction, 300 ml of dry ether was added to the reaction mixture to crystallize, whereby 34.9 g (89.4%) of HCl.H-Arg(NO2)-CHA was obtained.

Workup

  1. customThe solution was reacted at room temperature for 2 hours
  2. additionwas added to the reaction mixture
  3. customto crystallize

Sources & evidence

ORD record
ord-34831802275a497d9def4877daa42cd9
Source dataset
uspto-grants-1992_05
Patent number
US05116941

Reaction notes

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