HCID 124544363, compound → HCID 178451027, compound

Participants

Reaction Steps

After 4.4 g (10 mM) of H-Gly-Arg-CHA.2HCl was dissolved in 20 ml of 0.75N NEM/DMF, 4.3 g (10 mM) of Z-D-Glu(OtBu)-OSu was added to the solution while cooling to 0° to 5° C. with stirring. The resulting mixture was reacted at room temperature for 15 hours. After completion of the reaction, the solvent was distilled under reduced pressure. The residue was dissolved in MeOH and the solution was reprecipitated in 1 liter of AcOEt. The precipitated crystals were taken by filtration and dried to give 6.1 g (84.5%) of Z-D-Glu(OtBu)-Gly-Arg-CHA.HCl.

Provenance & Evidence