反应详情

To a mixture of 2.81 g of ethyl 4-nitro-2-[p-(4-phenylbutoxy)benzamido]phenoxyacetate obtained in Example 26 in 50 ml of ethanol-tetrahydrofuran (1:1) was added 0.5 g of palladium-carbon. Catalytic reduction was performed at room temperature under normal pressure until absorption of hydrogen was discontinued. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The obtained crystals were washed with isopropyl alcohol to obtain 1.72 g of ethyl 4-amino-2-[p-(4-phenylbutoxy)benzamido]phenoxyacetate.

1. customCatalytic reduction was performed at room temperature under normal pressure until absorption of hydrogen
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. washThe obtained crystals were washed with isopropyl alcohol