HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 14882494, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 2-Dimethylaminopyridine | HCID 21885 | — |
| Reactant | Dihydrocaffeic acid | HCID 348154 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14882494 | HCID 14882494 | 92.1% |
Reaction Steps
3 g of dihydrocaffeic acid and 1.43 g of morpholine were dissolved in 20 ml of DMF (dimethylformamide), and 202 mg of DMAP (dimethylaminopyridine) and 3.4 g of DCC (dicyclohexylcarbodiimide) were further added thereto under cooling, followed by allowing the mixture to stand overnight. The deposited dicyclohexyl urea was removed therefrom by filtration, and the resultant filtrate was then distilled off under reduced pressure. Afterward, the residue was washed with ether in order to obtain 3.8 g of N-[3-(3,4-dihydroxyphenyl)propionyl]morpholine in the state of light yellow crystals having a melting point of from 211° to 213° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05116979 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-efc5b1e7a11247aeb4a4d096c38faee3 |
| Source note | uspto-grants-1992_05 |