Acetaldehyde → HCID 14127108, compound

HRID 1197150Notes

Reaction equation

HRID 1197150 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH:6](=O)[CH3:7].[CH:9]([C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH2:18])=[O:17])=[CH:14][CH:13]=1)([CH3:11])[CH3:10]>C(O)(=O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([NH:18][C:16](=[O:17])[C:15]1[CH:19]=[CH:20][C:12]([CH:9]([CH3:11])[CH3:10])=[CH:13][CH:14]=1)[CH3:7]

Participants

5

Reactant 3

HCID 177AcetaldehydeHCID 8030ThiopheneHCID 69277Benzamide, 4-(1-methylethyl)-

Product 1

HCID 14127108HCID 14127108, compoundYield 7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Thiophene (25 mmol), acetaldehyde (20 mmol) and 4-isopropylbenzamide (10 mmol) were stirred in acetic acid (10 ml) at 60° C. for 4.5 hours to obtain N-[1-(2-thienyl)ethyl]-4-isopropylbenzamide. Yield: 7%. This result means that a general method which uses acetic acid as a solvent gives the product in a low yield.

Sources & evidence

ORD record
ord-1989594fd3844b289da3e55a5d4c9912
Source dataset
uspto-grants-1992_05
Patent number
US05117000

Reaction notes

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