HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Hexanedione → Ethyl 5,8-dimethylcarbazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Hexanedione | HCID 8035 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | Ethyl indole-4-carboxylate | HCID 605034 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 5,8-dimethylcarbazole-4-carboxylate | HCID 19897884 | 39.8% |
Reaction Steps
A mixture of 13.24 g of ethyl indole-4-carboxylate, 15.98 g of acetonylacetone and 13.31 g of p-toluenesulfonic acid monohydrate in 50 ml of ethanol was refluxed for 10 hours. The ethanol was evaporated under reduced pressure, the residue was chromatographed on silica gel column with hexane - ethyl acetate (9 : 1) to give 7.45 g of ethyl 5,8-dimethylcarbazole-4-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05116995 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-7011647797124f60ab76be0535658e02 |
| Source note | uspto-grants-1992_05 |