HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1197211Generated: October 26, 2026
Hydrochloric Acid → 3-(N-methylamino)aniline-4-sulfonic acid
https://huagongshe.com/reaction/1197211
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(N-acetylamino)aniline-4-sulfonic acid | HCID 19766995 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(N-methylamino)aniline-4-sulfonic acid | HCID 10965570 | — |
Reaction Steps
115 g of 3-(N-acetylamino)aniline-4-sulfonic acid in 430 ml of water and 70 g of formic acid were boiled under reflux for 7 hours. The mixture was cooled to 20° C. and its pH then adjusted to 12 with caustic soda solution. 75 g of dimethyl sulfate were then added, and after 40 minutes the pH was adjusted to -0.5 with hydrochloric acid. The mixture was heated under reflux for 3 hours and then salted out with 150 g of sodium chloride. The pH was adjusted to 1.0 with caustic soda solution, and the precipitated 3-(N-methylamino)aniline-4-sulfonic acid was isolated by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05117050 |
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| Source dataset | uspto-grants-1992_05 |
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| ORD ID | ord-c5ed07ea8d9946d18376aabbd64f628d |
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| Source note | uspto-grants-1992_05 |
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