反应详情

To a solution of N'-t-butyl-N'-3-toluoyl hydrazine (4.03 g, 0.02 mole) in methylene chloride (25 ml) under nitrogen was added 4-chlorobenzenesulfonyl isocyanate (5 g, 80%, 0.02 mole) at room temperature. The exothermic reaction mixture was stirred at room temperature for 30 minutes. The solvent was evaporated under reduced pressure to give an oil. A precipitate appeared after treating with ether. The pure product was collected by suctionfiltration and washed with a small amount of ether affording 4.8 g of 1-t-butyl-1-(3-toluoyl)-4-(4-chlorobenesulfonyl)semicarbazide as a white solid. m.p 184°-188° C.

1. customThe solvent was evaporated under reduced pressure
2. customto give an oil
3. filtrationThe pure product was collected by suctionfiltration
4. washwashed with a small amount of ether affording 4.8 g of 1-t-butyl-1-(3-toluoyl)-4-(4-chlorobenesulfonyl)semicarbazide as a white solid
5. customm.p 184°-188° C.