3-Fluoroundecyloxy methanesulfonate → (R)-5-Octyloxy-2-[4-(3-fluoroundecyloxy)phenyl]pyrimidine

HRID 1197391Notes

Reaction equation

HRID 1197391 reaction equation
[CH2:1]([O:9][C:10]1[CH:11]=[N:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[N:14][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].CS(OO[CH2:29][CH2:30][CH:31]([F:40])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])(=O)=O>>[CH2:1]([O:9][C:10]1[CH:15]=[N:14][C:13]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:29][CH2:30][C@H:31]([F:40])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:20][CH:21]=2)=[N:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 191056993-Fluoroundecyloxy methanesulfonateHCID 135708811Phenol, 4-[5-(octyloxy)-2-pyrimidinyl]-

Product 1

HCID 53813894(R)-5-Octyloxy-2-[4-(3-fluoroundecyloxy)phenyl]pyrimidineYield 19.5%

Procedure

The titled compound was synthesized from 5-octyloxy-2-(4-hydroxyphenyl)pyrimidine and 3-fluoroundecyloxy methanesulfonate.

Sources & evidence

ORD record
ord-cb52331e6b8c4e82b25bcddf329a1a1f
Source dataset
uspto-grants-1994_01
Patent number
US05275756

Reaction notes

Loading…