(R)-3-fluorohexanol → (R)-5-Decyl-2-[3-fluoro-4-(3-fluorohexyloxy)phenyl]pyrimidine

HRID 1197392Notes

Reaction equation

HRID 1197392 reaction equation
[CH2:1]([C:11]1[CH:12]=[N:13][C:14]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[C:19]([F:24])[CH:18]=2)=[N:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[F:25][C@H:26]([CH2:30][CH2:31][CH3:32])[CH2:27][CH2:28]O>>[CH2:1]([C:11]1[CH:12]=[N:13][C:14]([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:28][CH2:27][C@H:26]([F:25])[CH2:30][CH2:31][CH3:32])=[C:19]([F:24])[CH:18]=2)=[N:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 53824607(R)-3-fluorohexanolHCID 1358112062-Fluoro-4-(5-decylpyrimidine-2-yl)phenol

Product 1

HCID 53912519(R)-5-Decyl-2-[3-fluoro-4-(3-fluorohexyloxy)phenyl]pyrimidineYield 28.9%

Procedure

The titled compound was synthesized from 5-decyl-2-(3-fluoro-4-hydroxyphenyl)pyrimidine and (R)-3-fluorohexanol.

Sources & evidence

ORD record
ord-0712f9151e104f6c9740fc31fde45b3d
Source dataset
uspto-grants-1994_01
Patent number
US05275756

Reaction notes

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