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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1197393Generated: November 1, 2026

methyl (S)-3-hydroxyheptanoate → (R)-5-Hexyloxy-2-[4-(3-fluoroheptyloxy)phenyl]pyrimidine

https://huagongshe.com/reaction/1197393

Reaction equation

Participants

RoleNameHCIDCharge
Reactantmethyl (S)-3-hydroxyheptanoateHCID 10419468—
ReactantHCID 22850585HCID 22850585—
Reactant5-n-Hexyloxy-2-(4-hydroxy-3-fluorophenyl)pyrimidineHCID 135675015—
Product(R)-5-Hexyloxy-2-[4-(3-fluoroheptyloxy)phenyl]pyrimidineHCID 5393437248.5%

Reaction Steps

The titled compound was synthesized from (R)-3-fluoroheptyl methanesulfonate, derived from methyl (S)-3-hydroxyheptanoate (98.0% ee, [α]D20 =-8.71°), and 5-n-hexyloxy-2-(4-hydroxy-3-fluorophenyl)pyrimidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05275756
Source datasetuspto-grants-1994_01
ORD IDord-c1edb33f48a54609b069763986599c61
Source noteuspto-grants-1994_01