Sodium Methoxide → HCID 21694334, compound

Participants

Reaction Conditions

Reaction Steps

At -10° to 0° C. and over a period of 15 minutes, 26.1 g (0.145 mol) of 30% strength sodium methylate was added, while stirring, to 31.0 g (0.145 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoropyrimidine in 300 ml of methanol. The mixture was stirred for 30 minutes at 0° C. and for 1 hour at 25° C. The reaction mixture was evaporated down under reduced pressure and worked up as above. There was obtained 31.6 g (96.6% of theory) of the title compound as a colorless oil; nD22 =1.5039.

Provenance & Evidence