Sodium Methoxide → HCID 86747118, compound

Participants

Reaction Conditions

Reaction Steps

At 0° C. and over a period of 10 minutes, 4.7 g (0.026 mol) of 30% strength sodium methylate was added, while stirring, to 6.0 g (0.0263 mol) of 4-chlorodifluoromethoxy-6-fluoro-2-methylaminopyrimidine in 100 ml of methanol. The mixture was stirred for 1 hour at 0° C. and for 1 hour at 25° C. Conventional working up gave 6.3 g (100% of theory) of the title compound of melting point 49°-53° C.

Provenance & Evidence