HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Gla-aht
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)- | HCID 457982 | — |
| Product | Gla-aht | HCID 6475485 | — |
Reaction Steps
Anhydrothymidine (0.520 g, 2.319 mmol, as a dry white powder) was dissolved in anhydrous pyridine (10 ml) under an atmosphere of dry nitrogen, and to this stirred solution at room temperature was added GLA acid chloride (0.900 g, 3.02 mmol). Stirring was continued overnight after which period, TLC indicated complete loss of the starting material. The pyridine was
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05276020 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-f4b0413425a043e68a1a6429d3d68dea |
| Source note | uspto-grants-1994_01 |