HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → 3-Amino-4(3H)-quinazolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Benzoic acid, 2-amino-, hydrazide | HCID 94728 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-4(3H)-quinazolinone | HCID 63125 | — |
Reaction Steps
A mixture of 2-aminobenzhydrazide (7.16 g, 47.4 mmol) and triethyl orthoformate (8.3 mL, 49.9 mmol) in ethanol is heated at reflux for 3.5 hours under a nitrogen atmosphere, cooled and filtered to obtain the title product as a white solid, 6.06 g (79%), mp 209°-210.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05276038 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-db61151175604882a3da7076350c92bf |
| Source note | uspto-grants-1994_01 |