4-Bromophenyl isothiocyanate → 1-(p-Bromophenyl)-3-(3,4-dihydro-4-oxo-3-quinazolinyl)-2-thiourea

Participants

Reaction Steps

4-Bromophenyl isothiocyanate (2.51 g, 11.72 mmol) is added to a mixture of 3-amino-4(3H)quinazolinone (1.72 g, 10.66 mmol) in a 1,2-dichloroethane at reflux under a nitrogen atmosphere. The reaction mixture is heated at reflux for 2 days, cooled, washed with ether and filtered. The filter cake is dried to give the title product as a white solid, 2.44 g, mp 189°-190° C.

Provenance & Evidence