Boron Trichloride → HCID 15766707, compound

Participants

Reaction Steps

A 1.0 molar solution of boron trichloride in dichloromethane (24 mL, 24.0 mmol BCl3) is added to a mixture of 1-(p-bromophenyl)-3-(3,4-dihydro-8-methoxy-4-oxo-3-quinazolinyl)urea (3.08 g, 7.91 mmol) in dichloromethane. The reaction mixture is stirred for 20 hours at room temperature, adjusted to about pH 8 with sodium hydrogen carbonate and concentrated in vacuo to obtain a slurry. The slurry is filtered and the filter cake is washed with water and dried to give the title product as a white solid, 2.55 g, mp 276°-278° C., which is identified by 1HNMR spectral analysis.

Provenance & Evidence