HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Acetyl-4-(2',4'-difluorobenzoyl)piperidine | HCID 2740707 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | (2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride | HCID 18759874 | 83% |
Reaction Steps
The preceding ketone (40 g, 0.15 mol) was added to a mixture of 125 ml concentrated HCl and 125 ml acetic acid and refluxed for 16 hours, cooled, and concentrated in vacuo. The white residue was triturated with hot isopropanol, filtered, washed with Et2O and dried to give 32.3 g (83%) of 4-(2,4-difluorobenzoyl)-piperidine hydrochloride (III), m.p. 215°-216° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05276040 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-e0009f3e647146d0834d43b744c048ef |
| Source note | uspto-grants-1994_01 |