Diethyl Ether → HCID 178486935, compound

Participants

Reaction Steps

Methanesulphonic acid (2 ml) was added to a stirred suspension of 7.75 g of 4-fluoro-N-hydroxy-5,6-dimethoxybenzo[b]thiophene-2-carboximidamide in 20 ml of methanol. The starting material dissolved and the resultant solution was filtered dust-free, then concentrated under reduced pressure. Dust-free diethyl ether (20 ml) was then added to the residual oily crystalline residues and the mixture was stirred until a thick paste had formed. More dust-free diethyl ether (30 ml) was then added, the mixture was stirred again, then the solid was filtered and dried at 65° C. under vacuum to give 10 g of pure 4-fluoro-N-hydroxy-5,6-dimethoxybenzo[b]thiophene-2-carboximidamide methanesulphonate. M.p. 190° C. (dec.).

Provenance & Evidence