1-Indanone → HCID 15158872, compound

HRID 1197522Notes

Reaction equation

HRID 1197522 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([Mg]Br)=[CH:4][CH:3]=1.[C:10]1(=O)[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11]1>CCOCC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:10][CH:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 67351-IndanoneHCID 178418676HCID 178418676, compound

Product 1

HCID 15158872HCID 15158872, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of solution of 4-fluorophenylmagnesium bromide (prepared from 6.43 ml of 4-fluorobromobenzene and 1.71 g of Mg in 50 ml of ether) at room temperature under argon was added dropwise over 40 minutes a solution of 1-indanone (6.61 g, 50 mmole) in dry ether (20 ml). After stirring at room temperature for 1 hour, the reaction was quenched by the dropwise addition of saturated NH4Cl solution (15 ml). The mixture was diluted with Et2O, washed with saturated NaCl solution, dried (MgSO4) and evaporated.

Workup

  1. customthe reaction was quenched by the dropwise addition of saturated NH4Cl solution (15 ml)
  2. additionThe mixture was diluted with Et2O
  3. washwashed with saturated NaCl solution
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-8a3f9d8a676c4518b0bdf3933c184389
Source dataset
uspto-grants-1994_01
Patent number
US05276021

Reaction notes

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