Water → HCID 15657627, compound

Participants

Reaction Steps

The compound from Example 27 (42 g, 0.18 mole) and p-toluenesulfonic acid (6 g) were dissolved in 500 mL toluene and heated at reflux for 30 minutes with removal of water (Dean-Stark trap). The solution was cooled and washed with saturated sodium bicarbonate, dried over sodium sulfate, filtered and evaporated. The residual syrup was chromatographed on silica gel (0-3% ethyl acetate in heptane) to give the title compound in 93% yield.

Provenance & Evidence