5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole → HCID 178441783, compound

HRID 1197594Notes

Reaction equation

HRID 1197594 reaction equation
[CH2:1]([C:5]1[N:9]=[C:8]([N:10]2[CH:14]=[CH:13][CH:12]=[CH:11]2)[C:7]([CH2:18][OH:19])(C([O-])=O)[N:6]=1)[CH2:2][CH2:3][CH3:4].C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:27]2[C:31]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[C:38]3[CH:43]=[CH:42][C:41]([CH2:44]Br)=[CH:40][CH:39]=3)=[N:30][N:29]=[N:28]2)C=CC=CC=1>>[CH2:1]([C:5]1[N:6]([CH2:44][C:41]2[CH:42]=[CH:43][C:38]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=3[C:31]3[NH:27][N:28]=[N:29][N:30]=3)=[CH:39][CH:40]=2)[C:7]([CH2:18][OH:19])=[C:8]([N:10]2[CH:11]=[CH:12][CH:13]=[CH:14]2)[N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazoleHCID 19106936HCID 19106936, compound

Product 1

HCID 178441783HCID 178441783, compound

Procedure

Using the method described in Example 13, 2-butyl-5-(hydroxymethyl)-4-(1H-pyrrol-1-yl)imidazole-5-carboxylate (Example 29) and N-triphenylmethyl-5-[4'-(bromomethyl)biphenyl-2-yl]tetrazole (Example 12) are reacted and deprotected to give the title compound.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-b18254efaeef4967b69117042b10f781
Source dataset
uspto-grants-1994_01
Patent number
US05276048

Reaction notes

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