Thionyl Chloride → HCID 19107605, compound

Participants

Reaction Steps

Thionyl chloride (2.18 g, 0.018 mol) was slowly added to a stirred solution of 3-hydroxy-3,3-di(4-methoxyphenyl)propanenitrile (4.0 g, 0.014 mol) in pyridine (30 ml) cooled in an ice-salt bath. After the addition was complete the mixture was allowed to warm up to room temperature and stirred for 2 h. ice cold water (100 ml) was added and the mixture extracted with DCM (2×100 ml) The combined organics were washed with 3M hydrochloric acid (1×50 ml, 1×5 ml) , brine (50 ml) , dried over anhydrous sodium sulphate, filtered and evaporated to yield crude 3,3-di(4-methoxyphenyl)-2-propenenitrile (2.95 g, 79%) which was used directly in the next step.

Provenance & Evidence