Anisole → HCID 22420677, compound

Participants

Reaction Steps

To 2.57 g of 5,6-dichloro-1-isopropyl-2-methylbenzimidazole were added 1.52 ml of α-bromopropiophenone and 1 ml of anisole, and the mixture was heated for 2 hours on a steam bath. Then, to the mixture was added 50 ml of acetone. A produced crystals were separated from the mixture through filtration, then to the crystals were added 40 ml of 2% aqueous solution of sodium carbonate, and the resulting mixture was heated for 80 minutes on a steam bath. After the mixture was allowed to stand for cooling, produced crystals were separated from through filtration. The crystals were then washed with water to obtain 6,7-dichloro-4-isopropyl-1-methyl-2-phenylpyrrolo[1,2-a]benzimidazole.

Provenance & Evidence