Chloroform → HCID 131718303, compound

HRID 1197674Notes

Reaction equation

HRID 1197674 reaction equation
[Br:1][CH2:2][C:3]([CH:5]1[CH:10]2[CH:8]([C:9]2([CH3:12])[CH3:11])[C:7](=[O:13])[O:6]1)=[O:4].C(Cl)Cl.C(Cl)(Cl)Cl.[Br:21]Br>O>[Br:1][CH:2]([Br:21])[C:3]([CH:5]1[CH:10]2[CH:8]([C:9]2([CH3:11])[CH3:12])[C:7](=[O:13])[O:6]1)=[O:4]

Participants

6

Reactant 4

HCID 6212ChloroformHCID 6344DichloromethaneHCID 24408BromineHCID 131718304HCID 131718304, compound

Product 1

HCID 131718303HCID 131718303, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.125 g of (1R-(1 α, 4 β, 5α))-4-(bromoacetyl)-6,6-dimethyl-3-oxabicyclo [3.1.0] hexan-2-one of Example 3 were mixed under an inert ga atmosphere with 1 ml of methylene chloride and 1 ml of chloroform. 50 μl of bromine were added slowly at +25° to 30° C. and the mixture was stirred for 48 hours at ambient temperature. Water was added, followed by decanting and extracting with methylene chloride. The organic phase was dried and the solvent was evaporated under reduced pressure to obtain 0.199 g of the crude expected product in the form of an oil.

Workup

  1. customby decanting
  2. extractionextracting with methylene chloride
  3. customThe organic phase was dried
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-74d36dc664534f3a8ed612eee48ff4cc
Source dataset
uspto-grants-1994_01
Patent number
US05276167

Reaction notes

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