HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 737218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylbenzaldehyde | HCID 7725 | — |
| Reactant | Levulinic Acid | HCID 11579 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 737218 | HCID 737218 | 19.4% |
Reaction Steps
4-Tolualdehyde (39.6 g, 0.33 mol) and 2M NaOH solution (230 ml) are added to a solution of levulinic acid (39.5 g, 0.34 mol) in EtOH (85 ml) over 1 hour. The resulting clear solution is poured into ice and acidified with 6M HCl. The resulting gum obtained is crystallised with acetone/water and recrystallised from CH2Cl2 to yield 14.0 g of 6-(4 methylphenyl)-4-oxo-hex-5-enoic acid as colourless crystals m.p. 129-130.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05277709 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-45335385a0dd4380b8f11034fa4d7f59 |
| Source note | uspto-grants-1994_01 |