Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Prolinol | HCID 90908 | — |
| Reactant | 5-Fluoro-2-nitrotoluene | HCID 94956 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 19104591 | HCID 19104591 | 85.4% |
Reaction Steps
20 g of 5-fluoro-2-nitrotoluene, 14.3 g of 2-pyrrolidine methanol and 20 g of potassium carbonate were added to 100 ml of dimethylformamide. They were stirred at 100° C. for 2 h. After leaving to cool, the reaction mixture was poured into water. After extraction with ethyl acetate, the extract was washed with water, concentrated and recrystallized from acetonitrile to obtain 26 g of 2-hydroxymethyl-N-(3-methyl-4-nitrophenyl)pyrrolidine (d) as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05278034 |
|---|
| Source dataset | uspto-grants-1994_01 |
|---|
| ORD ID | ord-5ea683e842f041ea999a776089518de2 |
|---|
| Source note | uspto-grants-1994_01 |
|---|
