HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Diethyl 2-(3,4-dimethyl-5-phenyloxazolidin-2-yl)benzylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ephedrine | HCID 9294 | — |
| Reactant | Diethyl 2-formylbenzylphosphonate | HCID 19104780 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Diethyl 2-(3,4-dimethyl-5-phenyloxazolidin-2-yl)benzylphosphonate | HCID 19104778 | — |
Reaction Steps
2.0 g (8 mmol) of the compound A and 1.32 g (8 mmol) of (-)-ephedrine were dissolved in 100 ml of benzene and heated under reflux in a water separator for 24 h. The solvent was then removed by rotary evaporation and the residue was chromatographed on silica gel (eluent CH2Cl2 /ethanol 9.5/0.5; Rf=0.55). The product F was obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05278152 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-698f46525b45450794793f3ed944a5db |
| Source note | uspto-grants-1994_01 |