2-Hydrazinyl-3-(propan-2-yl)-5-(pyridin-3-yl)pyrazine → HCID 178471157, compound

HRID 1197794Notes

Reaction equation

HRID 1197794 reaction equation
[NH:1]([C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[N:7][C:6]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:5][N:4]=1)[NH2:2].[NH:18]1[CH:22]=[C:21]([CH2:23][CH:24]([C:30](OCC)=O)[C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=[CH:19]1>>[CH:9]([C:8]1[C:3]2[N:4]([C:30]([CH:24]([CH2:23][C:21]3[N:20]=[CH:19][NH:18][CH:22]=3)[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[N:2][N:1]=2)[CH:5]=[C:6]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:7]=1)([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 191049042-Hydrazinyl-3-(propan-2-yl)-5-(pyridin-3-yl)pyrazineHCID 178471159HCID 178471159, compound

Product 1

HCID 178471157HCID 178471157, compound

Procedure

In a manner analogous to Example 1, by condensing 2-hydrazino-3-isopropyl-5-(3-pyridyl)pyrazine with diethyl (imidazol-4-ylmethyl)malonate there is obtained ethyl rac-8-isopropyl-α-(imidazol-4-ylmethyl)-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, MS: 405 (M)+, which is converted into the above acid by alkaline saponification.

Sources & evidence

ORD record
ord-845945f5038348168122aec9507829be
Source dataset
uspto-grants-1994_01
Patent number
US05278161

Reaction notes

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