HCID 19104951, compound → HCID 178471155, compound

HRID 1197798Notes

Reaction equation

HRID 1197798 reaction equation
[CH2:1]([C:8]1[C:13]([NH:14][NH2:15])=[N:12][CH:11]=[C:10]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:22]1[CH:26]=[C:25]([CH2:27][CH:28]([C:34](OCC)=O)[C:29]([O:31][CH2:32][CH3:33])=[O:30])[N:24]=[CH:23]1>>[CH2:1]([C:8]1[C:13]2[N:12]([C:34]([CH:28]([CH2:27][C:25]3[N:24]=[CH:23][NH:22][CH:26]=3)[C:29]([O:31][CH2:32][CH3:33])=[O:30])=[N:15][N:14]=2)[CH:11]=[C:10]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 19104951HCID 19104951, compoundHCID 178471159HCID 178471159, compound

Product 1

HCID 178471155HCID 178471155, compound

Procedure

In a manner analogous to that described in Example 1, by condensing 2-benzyl-3-hydrazino-6-(3-pyridyl)pyrazine with diethyl (imidazol-4-ylmethyl)malonate there is obtained ethyl rac-8-benzyl-α-(imidazol-4-ylmethyl)-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, MS: 453 (M)+, which is converted into the above acid by alkaline saponification.

Sources & evidence

ORD record
ord-0966c1a153ed476e8e777e84fef11bd1
Source dataset
uspto-grants-1994_01
Patent number
US05278161

Reaction notes

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