Diethyl Malonate → HCID 19104906, compound

Participants

Reaction Steps

In a manner analogous to Example 1, by chlorinating 6-phenyl-4-propyl-3(2H)-pyridazinone [Chim. Ther. 6, 109 (1971)] there is obtained 3-chloro-6-phenyl-4-propylpyridazine, MS: 232 (M)+, which is converted by hydrazinolysis into 3-hydrazino-6-phenyl-4-propylpyridazine, MS: 228 (M)+. Subsequent ring condensation with diethyl malonate to ethyl 6-phenyl-8-propyl-s-triazolo[4,3-b]pyridazine-3-acetate, MS: 324 (M)+, followed by basic saponification gives the above acid as a solid, MS: 252 (M-CO2)+.

Provenance & Evidence