HCID 19104896, compound → HCID 178471156, compound

HRID 1197805Notes

Reaction equation

HRID 1197805 reaction equation
[NH:1]([C:3]1[C:8]([CH:9]([CH3:12])[CH2:10][CH3:11])=[N:7][C:6]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:5][N:4]=1)[NH2:2].[NH:19]1[CH:23]=[C:22]([CH2:24][CH:25]([C:31](OCC)=O)[C:26]([O:28][CH2:29][CH3:30])=[O:27])[N:21]=[CH:20]1>>[CH3:12][CH:9]([C:8]1[C:3]2[N:4]([C:31]([CH:25]([CH2:24][C:22]3[N:21]=[CH:20][NH:19][CH:23]=3)[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[N:2][N:1]=2)[CH:5]=[C:6]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:7]=1)[CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 19104896HCID 19104896, compoundHCID 178471159HCID 178471159, compound

Product 1

HCID 178471156HCID 178471156, compound

Procedure

In a manner analogous to Example 1, by condensing rac-2-hydrazino-3-(1-methylpropyl)-5-(3-pyridyl)pyrazine with diethyl (imidazol-4-ylmethyl)malonate there is obtained ethyl (RS)-8-[(RS)-1-methylpropyl]-α-(imidazol-4-ylmethyl)-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, MS: 419 (M)+, which is converted into the above acid by alkaline saponification.

Sources & evidence

ORD record
ord-7149188bb33b4b24bf0df82712132e03
Source dataset
uspto-grants-1994_01
Patent number
US05278161

Reaction notes

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