HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Chloromethyl)-2,5-dimethyloxazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (Dimethyl-1,3-oxazol-4-yl)methanol | HCID 7162083 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-(Chloromethyl)-2,5-dimethyloxazole hydrochloride | HCID 19105072 | 100% |
Reaction Steps
To a solution of 18.5 parts of 2,5-dimethyl-4-oxazolemethanol in 200 parts of trichloromethane there were added dropwise 21.1 parts of thionyl chloride. After stirring for 2 hours at room temperature, the reaction mixture was evaporated and the residue was co-evaporated with methylbenzene, yielding 26.4 parts (100%) of 4-(chloromethyl)-2,5-dimethyloxazole hydrochloride (interm. 26).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05278165 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-88cd125f5cd2406b9903f8649794ed6a |
| Source note | uspto-grants-1994_01 |