HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Methylhydroxylamine hydrochloride → 1-Azabicyclo[2.2.1]hept-4-yl-N-methoxycarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | Ethyl 1-azabicyclo[2.2.1]heptane-4-carboxylate hydrobromide | HCID 22922786 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-Azabicyclo[2.2.1]hept-4-yl-N-methoxycarboxamide | HCID 10583285 | — |
Reaction Steps
Ethyl 1-azabicyclo[2.2.1]hept-4-ylcarboxylate hydrobromide salt (D17, 16.85 g, 0.067 mole) was converted to the acid chloride hydrochloride salt and treated with methoxylamine hydrochloride (6.19 g, 0.074 mole) and triethylamine as in the method of Description 8 to give the title compound (D18) as a pale brown crystalline solid (4.60 g, 40%) m.p. 129°-134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05278170 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-88b53924938340f192c6abdcd9f47c09 |
| Source note | uspto-grants-1994_01 |