Hydrochloric Acid → HCID 178502024, compound

Participants

Reaction Steps

Methyl (±)-[5-[amino(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbamate (209 g, 0.67 mole) was suspended in 2.4 L of MeOH containing (1.5 m HCl) of 12N aq HCl and stirred at room temperature for 24 hours and then at 5° C. for 18 hours. The solid was collected by filtration. The salt was recrystallized by suspending the solid in MeOH (3 L) and adding water (250 mL) until a solution was obtained. The solution was filtered through a Celite pad and evaporated to dryness. The solid was again suspended in MeOH then collected by filtration yield: 175 g (66%) of the title dihydrochloride, mp.>315° C.

Provenance & Evidence