Hydrochloric Acid → HCID 3007744, compound

Participants

Reaction Steps

A mixture consisting of 17 (3.56 g, 0.01 mol), 2N potassium hydroxide and ethanol (95%; 35 ml) was stirred for 5 hrs. at 70° C. The resulting solution was diluted with water (70 ml), acidified with 12N hydrochloric acid, and extracted with ethyl acetate (3×20 ml). The collected organic extracts were washed with a saturated solution of sodium chloride to neutralization, dried on anhydrous sodium sulphate, and deprived of the solvent. A yellowish solid consisting of compound 18 was obtained (2.26 g; 69%). The product was found to be pure by thin-layer analysis (silicon dioxide-ethyl acetate:acetic acid 50:1). M.p. 181°-183° C. (via toluene). Anal. (C18H19NO5).

Provenance & Evidence