反应详情

12.3 g of p-anisidine were added in small fractions to a suspension of 18.6 g of 4-nitrobenzoic acid chloride in 100 ml of pyridine and the mixture was heated for 2 hours at reflux. After returning to ambient temperature, the solution was poured into 500 ml of iced water and the precipitate formed was separated and washed with water, then dried under reduced pressure at 80° C. to obtain 20 g of N-(4-methoxyphenyl)-4-nitrobenzamide melting at 200° C.

1. temperaturethe mixture was heated for 2 hours
2. temperatureat reflux
3. customAfter returning to ambient temperature
4. customthe precipitate formed
5. customwas separated
6. washwashed with water
7. customdried under reduced pressure at 80° C.