Chloroacetamide → HCID 19105302, compound

Participants

Reaction Steps

A reaction vessel was charged with 11.5 g (54.5 mmole) of [(3,4-dimethylphenyl)phenyl]methylamine dissolved in 200 ml of absolute ethanol. A mixture of 5.05 g (54 mmole) of chloracetamide and 4.62 g (55 mmole) of sodium bicarbonate was added to the reaction vessel and the solution was brought to refulux and held at reflux for 42 hours. Solvent was evaporated under reduced pressure and the residue was diluted with water. The aqueous phase was extracted with dichloromethane and the organic solution dried over potassium carbonate. After evaporation of solvent under reduced pressure, the solid residue was crystallized in ethyl acetate.

Provenance & Evidence