Iodoacetamide → HCID 19105303, compound

Participants

Reaction Steps

A reaction vessel was charged with 5 g (18.4 mmole) of [(2-chlorophenyl)-4-fluorophenyl]methylamine hydrochloride, 3.4 g (18.4 mmole) of iodoacetamide, 3.2 g (3.8 mmole) of sodium bicarbonate and 150 ml of absolute ethanol. The resulting suspension was brought to reflux and held at reflux for 42 hours. Solvent was evaporated under reduced pressure and the residue was dissolved in water. The aqueous phase was extracted with dichloromethane, and then the organic phase was dried over potassium bicarbonate and evaporated under reduced pressure. The brown oil was solidified in a mixture of ethyl acetate and pentane, and then crystallized twice in a mixture of ethyl acetate and pentane.

Provenance & Evidence