HCID 56982890, compound → HCID 67852594, compound

Participants

Reaction Steps

600 mg (1.69 mmol) of t-butyl [(1S)-1-(cyclohexylmethyl)-2-hydroxy-3-piperidinopropyl]carbamate were dissolved in 6 ml of 5.2N hydrochloric acid in dioxan and subsequently stirred at room temperature for 2 hours. Thereafter, the reaction solution was evaporated under reduced pressure, made alkaline with 25% ammonia solution and extracted with ether. Drying and evaporation of the ether extract yielded 400 mg (93%) of α-[(S)-1-amino-2-cyclohexylethyl]-1-piperidineethanol (αR:αS=5:1) as a resin, MS: 236 (M-H2O)+.

Provenance & Evidence