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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1197970Generated: October 25, 2026

2',5'-Dihydroxypropiophenone → 2-Cyclohexyl-6-[6-(4-hydroxypiperidinyl)hexoxy]-3-methyl-4H-1-benzopyran-4-one hydrochloride

https://huagongshe.com/reaction/1197970

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2',5'-DihydroxypropiophenoneHCID 70312—
ReactantCyclohexanecarbonyl chlorideHCID 75938—
ReactantPiperidin-4-olHCID 79341—
Reactant1-Bromo-6-chlorohexaneHCID 80516—
Product2-Cyclohexyl-6-[6-(4-hydroxypiperidinyl)hexoxy]-3-methyl-4H-1-benzopyran-4-one hydrochlorideHCID 18959704—

Reaction Steps

The compound was prepared by a method similar to Example 11 from 2',5'-dihydroxypropiophenone, cyclohexanecarbonyl chloride, 1-bromo-6-chlorohexane, and 4-hydroxypiperidine: mp 109°-110° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05278174
Source datasetuspto-grants-1994_01
ORD IDord-56e13e6904f24ad8bc708a97e02c3682
Source noteuspto-grants-1994_01