HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ketoprofen
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Dimethyl Carbonate | HCID 12021 | — |
| Reactant | (3-Benzoylphenyl)ethanenitrile | HCID 88857 | — |
| Product | Ketoprofen | HCID 3825 | 80% |
Reaction Steps
A mixture of (3-benzoylphenyl)acetonitrile (1 g), dimethyl carbonate (15 ml) and K2CO3 (3 g) in the 1:40:5 molar ratio, is reacted in a steel autoclave at the temperature of 140° C. for 10 hours and 30 minutes. After recovering DMC, 0.85 g of the title product are obtained, with a monomethylation selectivity >99% (80% yield), which is hydrolyzed to obtain ketoprofen by known methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05278333 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-613233541c0642cca829c568c7018a85 |
| Source note | uspto-grants-1994_01 |