3,4-dihydro-2H-pyran → HCID 14405876, compound

Participants

Reaction Steps

To a solution of 12-hydroxydodecanoic acid (10.0 g, 0.046 mol) in 150 mL THF, p-toluenesulfonic acid (0.087 g, 0.01 eq) was added followed by 3,4-dihydro-2H-pyran (5.95 g, 0.070 mol). After stirring this homogeneous reaction mixture for 16 hours at room temperature under a nitrogen atmosphere, NaHCO3 saturated solution was added to the mixture. The mixture was then extracted with methylene chloride, dried (MgSO4), and concentrated in vacuo (30° C.) to yield 13.0 g (0.043 mol, 94%) of the desired product.

Provenance & Evidence