HCID 72741958, compound → HCID 19105576, compound

HRID 1198054Notes

Reaction equation

HRID 1198054 reaction equation
[CH3:1][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[NH:13][C:14](=[O:33])[CH2:15][C:16](=[N:31]O)[CH2:17][CH:18]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:3]>[Ni].CO.N>[NH2:31][CH:16]([CH2:17][CH:18]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH2:15][C:14]([NH:13][C:5]1[C:4]([CH:2]([CH3:1])[CH3:3])=[CH:9][CH:8]=[CH:7][C:6]=1[CH:10]([CH3:12])[CH3:11])=[O:33]

Participants

4

Reactant 1

HCID 72741958HCID 72741958, compound

Product 1

HCID 19105576HCID 19105576, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 21705897Ammonia methanolSolvent

Procedure

The title compound was prepared by treating N-[2,6-bis(1-methylethyl)phenyl]-β-(hydroxyimino)-δ-phenylbenzenepentanamide (0.23 g, 0.53 mmol) with Raney nickel (0.2 g) in 50 mL methanol/ammonia at 25° C. for 18 hours (ΔP=13.7 psi). The reaction mixture was concentrated in vacuo to give a white solid, the title compound.

Workup

  1. customThe title compound was prepared
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customto give a white solid

Sources & evidence

ORD record
ord-5631abc799124c6898fb344c11821df1
Source dataset
uspto-grants-1994_01
Patent number
US05278326

Reaction notes

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