HCID 86747491, compound → HCID 54055012, compound

Participants

Reaction Steps

The ester from Step 3 (0.228 g, 0.39 mmol) wa hydrogenated over 10% palladium on charcoal in absolute ethanol (50 mL) under an atmosphere of hydrogen at 45 psi and 30° C. for 7 hours. The catalyst was filtered and the solvent removed in vacuo, giving the product (0.217 g, 95%) as a white solid, mp 69°-76° C.; IR (film) 1714 and 1660 cm-1 ; NMR (CDCl3) 1.48-1.93 (19H, m), 2.11.varies.2.17 (2H, m), 2.50-2.68 (1H, m), 3.14-3.65 (7H, m), 4.74 (1H, s), 5.11 (1H, bs), 6.00-6.13 (1H, m), 6.90-6.99 (3H, m), 7.08-7.22 (5H, m), 7.35 (1H, d, J 8.0 Hz), 7.54-7.58 (1H, m), 8.28 (1H, bs); Anal. (C35H43N3O5.0.5H2O) C, H. N.

Provenance & Evidence