反应详情

300 ml of toluene, 50 ml of methylsulphate and 7.36 g of tetrabutylammonium hydrogen sulphate are added to 125 g of sodium hydroxide pellets in 125 ml of water, then, with stirring, 0.33 mole (73.6 g) of 6-benzyloxyindole. Stirring is maintained for 15 minutes after the end of the evolution of heat. The reaction medium is diluted with 2 volumes of water. After separation of the organic phase, the aqueous phase is extracted with toluene. After washing the organic phases with water and drying them, the desired product is obtained by evaporation. It melts at 79° C.

1. stirringStirring
2. temperatureis maintained for 15 minutes after the end of the evolution
3. temperatureof heat
4. customAfter separation of the organic phase
5. extractionthe aqueous phase is extracted with toluene
6. washAfter washing the organic phases with water
7. customdrying them