HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Toluidine → 2-(2-Methylphenylamino)-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Toluidine | HCID 7242 | — |
| Reactant | 2-Chloro-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine | HCID 10356057 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2-Methylphenylamino)-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine hydrochloride | HCID 67850401 | — |
Reaction Steps
2-Chloro-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine (1.5 g, 0.0054 mol) and o-toluidine (1.3 g, 0.012 mol) were heated at 160° in an oil bath for 2 hours. The addition of methanol gave a solid which was collected by filtration and dried. Recrystallization from ethanolic HCl gave the title compound as a partial hydrochloride salt, (1.13 g), m.p. 210°-212°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05280026 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-ab6f9e43779641068b4d43b162cb37db |
| Source note | uspto-grants-1994_01 |